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Description:HighaffinityandselectiveHIF-2αinhibitor
ChemicalName:N-(3-Chloro-5-fluorophenyl)-4-nitro-2,1,3-benzoxADIazol-5-amine
Purity:≥99%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences
BiologicalActivity
HighaffinityandselectiveHIF-2αinhibitor(Kd=81nM).BindstotheHIF-2αPAS-Bdomain;disruptsHIF-2α-ARNTheterodimerization.Exhibits>60-foldselectivityforHIF-2αoverHIF-1α.DecreasesHIF-2αDNA-bindingandattenuatesexpressionofHIF-2αtargetgenesinvitro.
CompoundLibraries
TC-S7009isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
M.Wt | 308.65 |
Formula | C12H6ClFN4O3 |
Storage | StoreatRT |
Purity | ≥99%(HPLC) |
CASNumber | 1422955-31-4 |
PubChemID | 70697712 |
InChIKey | CDQUJZKBRAFWNG-UHFFFAOYSA-N |
Smiles | ClC1=CC(F)=CC(NC3=C([N+]([O-])=O)C2=NON=C2C=C3)=C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 30.86 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight308.65.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 3.24mL | 16.2mL | 32.4mL |
5mM | 0.65mL | 3.24mL | 6.48mL |
10mM | 0.32mL | 1.62mL | 3.24mL |
50mM | 0.06mL | 0.32mL | 0.65mL |
MolarityCalculator
MolarityCalculator
Calculatethemass,volume,orconcentrationrequiredforasolution.
ReconstitutionCalculator
ReconstitutionCalculator
DilutionCalculator
DilutionCalculator
Calculatethedilutionrequiredtoprepareastocksolution.
ProductDatasheets
CertificateofAnalysis/ProductDatasheet
SafetyDatasheet
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