BiologicalActivity
YAPinhibitor;disruptsYAP-TEADinteractions.EnhancestrypsincleavageofYAP(EC50=100nM).Inhibitsgrowthandproliferationofretinoblastomacells.Alsosuppressescancerstemcellpropertiesinvitro.SuppressesYAP-inducedliverovergrowthinmice.
TechnicalData
| M.Wt | 718.79 |
| Formula | C41H42N4O8 |
| Storage | Storeat-20°C |
| Purity | ≥97%(HPLC) |
| CASNumber | 129497-78-5 |
| PubChemID | 5362420 |
| InChIKey | YTZALCGQUPRCGW-ZSFNYQMMSA-N |
| Smiles | CC(C(/C=C4N/C([C@@]5(C)C4=CC=C(C(OC)=O)[C@H]5[C@](OC)=O)=CC6=NC(C(CCC(OC)=O)=C6C)=C3)=N2)=C(C=C)/C2=C/C1=C(C)C(CCC(O)=O)=C/3N1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 14.38 | 20 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight718.79.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 1.39mL | 6.96mL | 13.91mL |
| 5mM | 0.28mL | 1.39mL | 2.78mL |
| 10mM | 0.14mL | 0.7mL | 1.39mL |
| 50mM | 0.03mL | 0.14mL | 0.28mL |
MolarityCalculator
ReconstitutionCalculator
DilutionCalculator
ProductDatasheets
© 2005- 苏州蚂蚁淘生物科技有限公司 版权所有。
苏ICP备17049038号-11
苏公网安备 32059002001627号
声明：本网站部分产品受外界条件影响（包含但不限于进口国出口国政策限制等因素），无法提供销售服务，下单后，会由客服人员联系厂家确认后另行通知。部分危险品无法清关，请勿下单
我要提问
您的问题将推送给已购用户，TA们将会为你解答。