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Description:Gibberellin-analog(GA3)chemicaldimerizer;cellpermeable
ChemicalName:(1S,2S,4aR,4bR,7S,9aS,10S,10aR)-1,2,4b,5,6,7,8,9,10,10a-Decahydro-2,7-dihydroxy-1-methyl-8-methylene-13-oxo-4a,1-(epoxymethano)-7,9a-methanobenz[a]azulene-10-aceticacid(acetyloxy)methylester
Purity:≥90%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences
BiologicalActivity
Gibberellin-analog(GA3)chemicaldimerizer;inducesrapiddimerizationofGAIsandGID1.GA3-AMcrossestheplasmamembrane,iscleavedbycytosolicesterasereleasingGA3,whichthenbindsGID1-thiscomplextheninturnformsacomplexwithGAI;thissystemworksonatimescaleofseconds(EC50=310nM).GA3andrapamycin(Cat.No.1292)chemicallyinducIBLedimerizationsystemsareorthogonal.Cellpermeable.
TechnicalData
M.Wt | 418.44 |
Formula | C22H26O8 |
Storage | Storeat-20°C |
Purity | ≥90%(HPLC) |
CASNumber | 1373154-68-7 |
PubChemID | 56835187 |
InChIKey | IVIYFJSPDLOPEX-SEWSRMJOSA-N |
Smiles | [H][C@@]12[C@@](C[C@@]3(O)CC2)(CC3=C)[C@@H](C(OCOC(C)=O)=O)[C@]4([H])[C@@]5(C)[C@@H](O)C=C[C@]41OC5=O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 41.84 | 100 | |
ethanol | 41.84 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight418.44.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 2.39mL | 11.95mL | 23.9mL |
5mM | 0.48mL | 2.39mL | 4.78mL |
10mM | 0.24mL | 1.19mL | 2.39mL |
50mM | 0.05mL | 0.24mL | 0.48mL |
MolarityCalculator
MolarityCalculator
Calculatethemass,volume,orconcentrationrequiredforasolution.
ReconstitutionCalculator
ReconstitutionCalculator
DilutionCalculator
DilutionCalculator
Calculatethedilutionrequiredtoprepareastocksolution.
ProductDatasheets
CertificateofAnalysis/ProductDatasheet
SafetyDatasheet


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