Clodronate SUV PEG Liposomes

Artificial spheres consisting of a single phospholipid bilayer encapsulating an aqueous PBS (phosphate buffered saline) solution containing clodronate. A special PEG-containing lipid is added to the composition, which allows for long circulation in blood and slower degradation of the formulation. The Liposomal suspension has been extruded and sized to 200nm in diameter and will not tend to precipitate upon storage. The concentration of clodronate in the suspension is ca. 5 mg/ml.

Upon request, the size can be reduced to 120-150nm with an extra extrusion step.

Control SUV PEG Liposomes

Control liposomes do not contain clodronate. Containing PBS only, they can be used for control experiments, in order to find out whether the effects observed after injection of clodronate liposomes are due to macrophage depletion exclusively. The Liposomal dispersion has been prepared with a special PEG-containing lipid which allows for long circulation in blood and slower degradation of the formulation. This formulation has been extruded and sized to 200nm in diameter which makes it the preferred control for the Clodronate SUV PEG liposomes.

Upon request, the size can be reduced to 120-150nm with an extra extrusion step.

Liposoma在开发脂质体配方方面有40多年的经验，主要生产氯膦酸脂质体、空白对照品脂质体和荧光标记脂质体，他们将知名脂质体学者的知识整合到了他们的脂质体技术中，创造了真正由磷脂囊泡组成的脂质体产品，而不是含有磷脂作为表面活性剂的乳剂，确保了活性物质被囊泡真正的包裹，而不是仅仅存在于脂质体之间（而且大部分在脂质体之外）。

Clodronateliposomes

氯膦酸脂质体C-005

由包裹含有氯膦酸盐的PBS（磷酸盐缓冲盐水）水溶液的同心磷脂双层组成的人工球体。脂质体是微粒，最大粒径为3微米。它们在PBS中形成悬浮液，储存时容易沉淀，在管或烧瓶底部形成颗粒。实验动物给药前应摇动混悬液，以恢复均匀的混悬液。

Liposoma常用产品报价单