BiologicalActivity
Hypolipidemicagent.Exhibitshigherpotencythannicotinicacidandclofibrate.FullandpotentagonistatthehumanorphanGPCRHM74A/GPR109AandGPR109B(EC50valuesare1.3 and4.2μMrespectively).ReducesserumtriglyceridesandcirculatingLDL-cholesterolinvivo,withoutaffectingliverweightorliverenzymes.
CompoundLibraries
AcifranisalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 218.21 |
| Formula | C12H10O4 |
| Storage | Storeat+4°C |
| Purity | ≥99%(HPLC) |
| CASNumber | 72420-38-3 |
| PubChemID | 51576 |
| InChIKey | DFDGRKNOFOJBAJ-UHFFFAOYSA-N |
| Smiles | CC1(OC(=CC1=O)C(O)=O)C1=CC=CC=C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 21.82 | 100 | |
| ethanol | 21.82 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight218.21.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 4.58mL | 22.91mL | 45.83mL |
| 5mM | 0.92mL | 4.58mL | 9.17mL |
| 10mM | 0.46mL | 2.29mL | 4.58mL |
| 50mM | 0.09mL | 0.46mL | 0.92mL |
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