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Description:Hypolipidemicagent;agoNISTfortheGPR109A(HM74A)andGPR109Breceptors
AlternativeNames:AY25712
ChemicalName:4,5-Dihydro-5-methyl-4-oxo-5-phenyl-2-furancarboxylicacid
Purity:≥99%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences
BiologicalActivity
Hypolipidemicagent.Exhibitshigherpotencythannicotinicacidandclofibrate.FullandpotentagonistatthehumanorphanGPCRHM74A/GPR109AandGPR109B(EC50valuesare1.3 and4.2μMrespectively).ReducesserumtriglyceridesandcirculatingLDL-cholesterolinvivo,withoutaffectingliverweightorliverenzymes.
CompoundLibraries
AcifranisalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
M.Wt | 218.21 |
Formula | C12H10O4 |
Storage | Storeat+4°C |
Purity | ≥99%(HPLC) |
CASNumber | 72420-38-3 |
PubChemID | 51576 |
InChIKey | DFDGRKNOFOJBAJ-UHFFFAOYSA-N |
Smiles | CC1(OC(=CC1=O)C(O)=O)C1=CC=CC=C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 21.82 | 100 | |
ethanol | 21.82 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight218.21.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 4.58mL | 22.91mL | 45.83mL |
5mM | 0.92mL | 4.58mL | 9.17mL |
10mM | 0.46mL | 2.29mL | 4.58mL |
50mM | 0.09mL | 0.46mL | 0.92mL |
MolarityCalculator
MolarityCalculator
Calculatethemass,volume,orconcentrationrequiredforasolution.
ReconstitutionCalculator
ReconstitutionCalculator
DilutionCalculator
DilutionCalculator
Calculatethedilutionrequiredtoprepareastocksolution.
ProductDatasheets
CertificateofAnalysis/ProductDatasheet
SafetyDatasheet
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