BiologicalActivity
RetinoicacidanalogthatisaRARβandRARγagonist(AC50valuesare2.2,9.3,22and>1000nMforRARβ,RARγ,RARαandRXRαreceptorsrespectively).Inhibitsproliferationandinducesapoptosisincolorectalcancercellinvitro.Displayscomedolyticactivity.
CompoundLibraries
AdapaleneisalsoofferedaspartoftheTocriscreenPlusandTocriscreenLibraryofFDA-ApprovedCompounds.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 412.52 |
| Formula | C28H28O3 |
| Storage | Storeat+4°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 106685-40-9 |
| PubChemID | 60164 |
| InChIKey | LZCDAPDGXCYOEH-UHFFFAOYSA-N |
| Smiles | COC1=CC=C(C3=CC=C(C=C(C(O)=O)C=C4)C4=C3)C=C1C25CC(C6)CC(CC6C5)C2 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 10.31 | 25 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight412.52.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.42mL | 12.12mL | 24.24mL |
| 5mM | 0.48mL | 2.42mL | 4.85mL |
| 10mM | 0.24mL | 1.21mL | 2.42mL |
| 50mM | 0.05mL | 0.24mL | 0.48mL |
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