BiologicalActivity
AgonistofadiponectinreceptorsAdipoR1andAdipoR2(Kdvaluesare1.8and3.1μMrespectively).ActivatesAMPKandPPARαsignaling;amelioratesinsulinresistance,dyslipidemiaandglucoseintoleranceindb/dbmice.Orallyactiveantidiabeticagent.
CompoundLibraries
AdipoRonhydrochlorideisalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 464.98 |
| Formula | C27H28N2O3.HCl |
| Storage | DesiccateatRT |
| Purity | ≥98%(HPLC) |
| CASNumber | 1781835-20-8 |
| PubChemID | 78243714 |
| InChIKey | TZVJQEGKRLDTHQ-UHFFFAOYSA-N |
| Smiles | O=C(C2=CC=C(OCC(NC3CCN(CC4=CC=CC=C4)CC3)=O)C=C2)C1=CC=CC=C1.Cl |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 46.5 | 100 | |
| ethanol | 4.65 | 10 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight464.98.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.15mL | 10.75mL | 21.51mL |
| 5mM | 0.43mL | 2.15mL | 4.3mL |
| 10mM | 0.22mL | 1.08mL | 2.15mL |
| 50mM | 0.04mL | 0.22mL | 0.43mL |
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