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Tocris/Alfuzosin hydrochloride/3305/50/50 mg

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Tocris/Alfuzosin hydrochloride/3305/50/50 mg

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Tocris

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3305/50

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4000-520-616

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Description:Uroselectiveα₁antagoNIST

ChemicalName:N-[3-[(4-Amino-6,7-dimethoxy-2-quinazolinyl)methylamino]propyl]tetrahydro-2-furancarboxamidehydrochloride

Purity:≥99%(HPLC)

BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

Functionallyuro-selectiveα₁adrenoceptorantagonistthatdoesnotdiscriminatebetweenα₁subtypes.Inhibitsincreasesinintraurethralpressurecausedbyphenylephrine-inducedcontractionby81%withminorcardiovasculareffects.Alsorelaxescorpuscavernosumtissue(pIC₅₀=7.64)invitro.

TechnicalData

M.Wt	425.91
Formula	C₁₉H₂₇N₅O₄.HCl
Storage	StoreatRT
Purity	≥99%(HPLC)
CASNumber	81403-68-1
PubChemID	71764
InChIKey	YTNKWDJILNVLGX-UHFFFAOYSA-N
Smiles	NC2=NC(N(C)CCCNC(C3CCCO3)=O)=NC1=CC(OC)=C(OC)C=C12.Cl

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

	Solvent	MaxConc.mg/mL	MaxConc.mM
Solubility
	DMSO	10.65	25
	water	10.65	25

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight425.91.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	2.35mL	11.74mL	23.48mL
5mM	0.47mL	2.35mL	4.7mL
10mM	0.23mL	1.17mL	2.35mL
50mM	0.05mL	0.23mL	0.47mL

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