BiologicalActivity
Potent,selectivedopamineD2andD3receptorantagonist.Kivaluesare2.8and3.2nMrespectivelyforhumanD2andD3and>1000nMforhumanD1,D4andD5receptors.ShowsselectivityforpresynapticdopamineautoreceptorsatlowdosesandblockspostsynapticD2/D3receptorsathigherdoses.PreferentiallyinteractswithlimbicD2-likereceptorsinvivo.Atypicalantipsychotic/antischizophrenicagentwithlimitedextrapyrimidalsideeffectsandaprofiledistinctfromthatofhaloperidolandremoxipride.
TechnicalData
| M.Wt | 369.48 |
| Formula | C17H27N3O4S |
| Storage | Storeat-20°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 71675-85-9 |
| PubChemID | 2159 |
| InChIKey | NTJOBXMMWNYJFB-UHFFFAOYSA-N |
| Smiles | CCN1CCCC1CNC(=O)C1=C(OC)C=C(N)C(=C1)S(=O)(=O)CC |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| 1eq.HCl | 9.24 | 25mMwithgentlewarming | |
| DMSO | 18.47 | 50 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight369.48.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.71mL | 13.53mL | 27.07mL |
| 5mM | 0.54mL | 2.71mL | 5.41mL |
| 10mM | 0.27mL | 1.35mL | 2.71mL |
| 50mM | 0.05mL | 0.27mL | 0.54mL |
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