Tocris产品目录价格 TOCRIS 4372-10MG,Tocris/Antisauvagine-30/2071/1/1 mg,受体,生物分子,生化试剂,,Tocris Bioscience蚂蚁淘商城

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Tocris/Antisauvagine-30/2071/1/1 mg

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Tocris

货号 /

2071/1

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4000-520-616

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Description:Potent,selectiveandcompetitiveCRF₂antagoNIST

AlternativeNames:[D-Phe¹¹,His¹²]-Sauvagine(11-40)

BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

Potent,selectiveandcompetitivecorticotropin-releasingfactorCRF₂receptorantagonist(K_dvaluesare1.4and153.6nMforbindingtomouseCRF_2βandratCRF₁receptorsrespectively).Inhibitssauvagine-stimulatedcAMPaccumulationinHEK-mCRF_2βcells(pA₂=8.49).Preventsstress-enhancedfearconditioningandMEK1/2-dependentactivationofERK1/2inmiceinvivo.

LicensingInformation

SoldwiththepermissionoftheMaxPlanckInstitute

TechnicalData

M.Wt	3650.29
Formula	C₁₆₁H₂₇₄N₄₈O₄₆S
Sequence	FHLLRKMIEIEKQEKEKQQAANNRLLLDTI (Modifications:Phe-1=D-Phe,Ile-30=C-terminalamide)
Storage	Desiccateat-20°C
CASNumber	220673-95-0
PubChemID	16138449
InChIKey	INBLUEDNNZCTNZ-JBNJRNGTSA-N
Smiles	[H]N[C@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCSC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H]([C@@H](C)CC)C(N)=O

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

Solubility	Solubleto1mg/mlinwater

Solubility

Solubleto1mg/mlinwater

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight3650.29.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	0.27mL	1.37mL	2.74mL
5mM	0.05mL	0.27mL	0.55mL
10mM	0.03mL	0.14mL	0.27mL
50mM	0.01mL	0.03mL	0.05mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet

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BiologicalActivity

LicensingInformation

TechnicalData

SolubilityData

PreparingStockSolutions

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