BiologicalActivity
PPARγpureantagonistwithmicromolaraffinityin3T3-L1and3T3-F442ApreADIpocytecells;selectiveoverPPARδandPPARα.AntagonizestheABIlityofrosiglitazonetostimulatetranscriptionalactivityofPPARγ.ActsasaPPARγagonistinanECV304cellline.AlsoproducesPPARγ-independentapoptosisoftumorcellsviaseveralmechanisms.Activeinvivo.
TechnicalData
| M.Wt | 340.42 |
| Formula | C21H24O4 |
| Storage | Desiccateat-20°C |
| Purity | ≥95%(HPLC) |
| CASNumber | 1675-54-3 |
| PubChemID | 2286 |
| InChIKey | LCFVJGUPQDGYKZ-UHFFFAOYSA-N |
| Smiles | CC(C)(C1=CC=C(OCC2CO2)C=C1)C1=CC=C(OCC2CO2)C=C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 34.04 | 100 | |
| ethanol | 17.02 | 50 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight340.42.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.94mL | 14.69mL | 29.38mL |
| 5mM | 0.59mL | 2.94mL | 5.88mL |
| 10mM | 0.29mL | 1.47mL | 2.94mL |
| 50mM | 0.06mL | 0.29mL | 0.59mL |
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