BiologicalActivity
PotentandselectiveNOPreceptorantagonist(IC50valuesare0.27,2500,6700and>10000nMforNOP,κ-,μ-andδ-receptorsrespectively).Inhibitsnociceptin-inducedstimulationof[35S]-GTPγSbindingandCa2+mobilizationinCHOcellsinvitroandantagonizesNOPagonist-inducedreductioninlocomotoractivityinvivo.Brainpenetrant.
CompoundLibraries
BANORL24isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 506.51 |
| Formula | C27H35N3O2.2HCl |
| Storage | Storeat-20°C |
| Purity | ≥97%(HPLC) |
| CASNumber | 1401463-54-4 |
| PubChemID | 56840444 |
| InChIKey | NEEVITHVDIQNJY-KHZPMNTOSA-N |
| Smiles | O=[C@@]([C@H]2CCCN2CC3=CC=CC=C3)NCCCN1CCC4(OCC5=C4C=CC=C5)CC1.Cl.Cl |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 50.65 | 100 | |
| water | 50.65 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight506.51.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 1.97mL | 9.87mL | 19.74mL |
| 5mM | 0.39mL | 1.97mL | 3.95mL |
| 10mM | 0.2mL | 0.99mL | 1.97mL |
| 50mM | 0.04mL | 0.2mL | 0.39mL |
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