BiologicalActivity
PotentadenosineA2Breceptoragonist(EC50=2.83nMformurineA2Breceptor).DisplaysselectivityforA2BoverA1,A2AandA3receptors.DecreasesfMLP-inducedsuperoxideproductioninneutrophilsatlowconcentrations(1-10nM).Cardioprotective;attenuatesinfarctsizeinamousemodelofmyocardialischemia.
CompoundLibraries
BAY60-6583isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 379.44 |
| Formula | C19H17N5O2S |
| Storage | Storeat+4°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 910487-58-0 |
| PubChemID | 11717831 |
| InChIKey | ZTYHZMAZUWOXNC-UHFFFAOYSA-N |
| Smiles | NC1=NC(SCC(N)=O)=C(C#N)C(C2=CC=C(OCC3CC3)C=C2)=C1C#N |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 37.94 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight379.44.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.64mL | 13.18mL | 26.35mL |
| 5mM | 0.53mL | 2.64mL | 5.27mL |
| 10mM | 0.26mL | 1.32mL | 2.64mL |
| 50mM | 0.05mL | 0.26mL | 0.53mL |
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