BiologicalActivity
Neutralretinoicacidreceptor(RAR)α-selectiveantagonist(Ki=2.5nM).Displaysnosignificanteffectonnuclearreceptorcorepressor(NCoR)binding;moderatelydecreasesSMRTbindingtoRAR.Antagonizesagonist-inducedcoactivator(CoA)recruitment.
TechnicalData
| M.Wt | 448.51 |
| Formula | C29H24N2O3 |
| Storage | Storeat-20°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 253310-42-8 |
| PubChemID | 445091 |
| InChIKey | WGLMBRZXZDAQHP-UHFFFAOYSA-N |
| Smiles | O=C(NC4=CC=C(C(O)=O)C=C4)C3=CC1=C(C=C3)C(C)(C)CC=C1C2=CN=C(C=CC=C5)C5=C2 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 11.21 | 25 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight448.51.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.23mL | 11.15mL | 22.3mL |
| 5mM | 0.45mL | 2.23mL | 4.46mL |
| 10mM | 0.22mL | 1.11mL | 2.23mL |
| 50mM | 0.04mL | 0.22mL | 0.45mL |
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