BiologicalActivity
Highlypotentandselectiveandrogenreceptor(AR)agonist(EC50=0.44nM).ExhibitsselectivityforARsoverestrogen,glucocorticoidandmineralocorticoidreceptorsandnosignificantbindingtosteroidhormonebindingglobulinoraromatase.AlsoexhibitsselectivityformuscleoverprostateARs.Activeinvivoandorallybioavailable.
TechnicalData
| M.Wt | 305.72 |
| Formula | C14H12ClN3O3 |
| Storage | Storeat-20°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 627530-84-1 |
| PubChemID | 49823417 |
| InChIKey | KEJORAMIZFOODM-UHFFFAOYSA-N |
| Smiles | [H][C@@]12[C@H](O)CCN1C(=O)N(C2=O)C1=CC=C(C#N)C(Cl)=C1C |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 30.57 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight305.72.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 3.27mL | 16.35mL | 32.71mL |
| 5mM | 0.65mL | 3.27mL | 6.54mL |
| 10mM | 0.33mL | 1.64mL | 3.27mL |
| 50mM | 0.07mL | 0.33mL | 0.65mL |
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