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Description:Highaffinity,potentCCR2antagoNIST
ChemicalName:2-[(Isopropylaminocarbonyl)amino]-N-[2-[[cis-2-[[4-(methylthio)benzoyl]amino]cyclohexyl]amino]-2-oxoethyl]-5-(trifluoromethyl)benzamide
Purity:≥98%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences
BiologicalActivity
HighaffinityCCR2chemokinereceptorantagonist(IC50=5.1nM).Displayspotentfunctionalantagonism,IC50valuesare1and18nMforchemotaxisandantagonismofcalciumfluxrespectively.SelectiveoverCCR3.
CompoundLibraries
BMSCCR222isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
M.Wt | 593.66 |
Formula | C28H34F3N5O4S |
Storage | Storeat+4°C |
Purity | ≥98%(HPLC) |
CASNumber | 445479-97-0 |
PubChemID | 24801690 |
InChIKey | IBPXYDUJQWENPM-XZOQPEGZSA-N |
Smiles | O=C(N[C@@H]2CCCC[C@@H]2NC(CNC(C3=C(NC(NC(C)C)=O)C=CC(C(F)(F)F)=C3)=O)=O)C1=CC=C(SC)C=C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 59.37 | 100 | |
ethanol | 5.94 | 10 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight593.66.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 1.68mL | 8.42mL | 16.84mL |
5mM | 0.34mL | 1.68mL | 3.37mL |
10mM | 0.17mL | 0.84mL | 1.68mL |
50mM | 0.03mL | 0.17mL | 0.34mL |
MolarityCalculator
MolarityCalculator
Calculatethemass,volume,orconcentrationrequiredforasolution.
ReconstitutionCalculator
ReconstitutionCalculator
DilutionCalculator
DilutionCalculator
Calculatethedilutionrequiredtoprepareastocksolution.
ProductDatasheets
CertificateofAnalysis/ProductDatasheet
SafetyDatasheet


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