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Tocris/BMS CCR2 22/3129/50/50 mg
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Tocris/BMS CCR2 22/3129/50/50 mg
品牌 / 
Tocris
货号 / 
3129/50
美元价:
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数    量:
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4000-520-616
Description:Highaffinity,potentCCR2antagoNIST
ChemicalName:2-[(Isopropylaminocarbonyl)amino]-N-[2-[[cis-2-[[4-(methylthio)benzoyl]amino]cyclohexyl]amino]-2-oxoethyl]-5-(trifluoromethyl)benzamide
Purity:≥98%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

HighaffinityCCR2chemokinereceptorantagonist(IC50=5.1nM).Displayspotentfunctionalantagonism,IC50valuesare1and18nMforchemotaxisandantagonismofcalciumfluxrespectively.SelectiveoverCCR3.

CompoundLibraries

BMSCCR222isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.

TechnicalData

M.Wt593.66
FormulaC28H34F3N5O4S
StorageStoreat+4°C
Purity≥98%(HPLC)
CASNumber445479-97-0
PubChemID24801690
InChIKeyIBPXYDUJQWENPM-XZOQPEGZSA-N
SmilesO=C(N[C@@H]2CCCC[C@@H]2NC(CNC(C3=C(NC(NC(C)C)=O)C=CC(C(F)(F)F)=C3)=O)=O)C1=CC=C(SC)C=C1

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
DMSO59.37100
ethanol5.9410

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight593.66.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM1.68mL8.42mL16.84mL
5mM0.34mL1.68mL3.37mL
10mM0.17mL0.84mL1.68mL
50mM0.03mL0.17mL0.34mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet