BiologicalActivity
Apotent5-ht1E/1Freceptoragonist(pEC50valuesare8.5and8.6respectively).Displays>30-foldselectivityoverother5-HTanddopaminereceptors(pKivaluesare8.7.8.9,7.2,6.9,7.2,5.9,7.0,6.5,<6,<6,6.3and6.2forhuman5-HT1E,1F,1A,1B,1D,2A,2B,2C,4,7,D2andD3receptorsrespectively).Induces5-HT2Areceptor-mediatedmouseaorticcontractioninvitro(pEC50=6.52).Activeinvivo.
TechnicalData
| M.Wt | 230.31 |
| Formula | C14H18N2O |
| Storage | Desiccateat+4°C |
| CASNumber | 57477-39-1 |
| PubChemID | 2438 |
| InChIKey | WKNFADCGOAHBPG-UHFFFAOYSA-N |
| Smiles | CN1CCC(CC1)C1=CNC2=CC=C(O)C=C12 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solubility | Solubleto50mMinDMSO |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight230.31.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 4.34mL | 21.71mL | 43.42mL |
| 5mM | 0.87mL | 4.34mL | 8.68mL |
| 10mM | 0.43mL | 2.17mL | 4.34mL |
| 50mM | 0.09mL | 0.43mL | 0.87mL |
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