BiologicalActivity
PotentandselectiveRXRagonist(EC50valuesare24,25and33nMforRXRβ,RXRγandRXRα,respectively).Exhibits>300-foldselectivityforRXRoverRARreceptors.Inhibitstumorcellinvasionandmigrationinvitro,andinhibitsmetastasisandangiogenesisinmousemodels.AlsopromotesbrownADIpogenicdifferentiationandinducesbrownadipogenicreprogrammingfrommyoblasts.
TechnicalData
| M.Wt | 348.48 |
| Formula | C24H28O2 |
| Storage | Storeat+4°C |
| Purity | ≥99%(HPLC) |
| CASNumber | 153559-49-0 |
| PubChemID | 82146 |
| InChIKey | NAVMQTYZDKMPEU-UHFFFAOYSA-N |
| Smiles | CC(CCC(C)2C)(C)C1=C2C=C(C)C(C(C3=CC=C(C(O)=O)C=C3)=C)=C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 34.85 | 100 | |
| ethanol | 6.97 | 20mMwithgentlewarming |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight348.48.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.87mL | 14.35mL | 28.7mL |
| 5mM | 0.57mL | 2.87mL | 5.74mL |
| 10mM | 0.29mL | 1.43mL | 2.87mL |
| 50mM | 0.06mL | 0.29mL | 0.57mL |
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