BiologicalActivity
MuscarinicreceptorantagonistthatdisplayssomeselectivityfortheM1subtype(Kivaluesare0.48,2.4,3.9,6.3and6.3nMforM1,M4,M3,M2andM5receptorsrespectively).Alleviatesextrapyramidalsymptomsassociatedwithantipsychoticdrugs.Displaysantiparkinsonianactivity.
TechnicalData
| M.Wt | 347.92 |
| Formula | C21H29NO.HCl |
| Storage | Desiccateat+4°C |
| Purity | ≥99%(HPLC) |
| CASNumber | 1235-82-1 |
| PubChemID | 92151 |
| InChIKey | RDNLAULGBSQZMP-UHFFFAOYSA-N |
| Smiles | OC(CCN3CCCCC3)(C4=CC=CC=C4)C1CC2C=CC1C2.Cl |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 3.48 | 10 | |
| water | 1.74 | 5 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight347.92.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.87mL | 14.37mL | 28.74mL |
| 5mM | 0.57mL | 2.87mL | 5.75mL |
| 10mM | 0.29mL | 1.44mL | 2.87mL |
| 50mM | 0.06mL | 0.29mL | 0.57mL |
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