BiologicalActivity
Potentarylhydrocarbonreceptor(AhR)antagonist(IC50=30nM).ExhibitsnoAhRagonist-likeactivity(atconcentrationsupto100μM).Inhibits2,3,7,8-Tetrachlorodibenzo-p-dioxin(TCDD)-inducedAhR-dependenttranscriptioninvitroandreducesTCDD-inducedtoxicityinvivo.AttenuatesTh17differentiationofnaiveCD4Tcellsandpromotesexpansionofhematopoieticstemcellsinvitro.
CompoundLibraries
CH223191isalsoofferedaspartoftheTocriscreenStemCellToolbox.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 333.39 |
| Formula | C19H19N5O |
| Storage | Storeat+4°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 301326-22-7 |
| PubChemID | 3091786 |
| InChIKey | LKTNEXPODAWWFM-UHFFFAOYSA-N |
| Smiles | CC1=C(/N=N/C2=CC=C(NC(C3=CC=NN3C)=O)C(C)=C2)C=CC=C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 33.34 | 100 | |
| ethanol | 3.33 | 10 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight333.39.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 3mL | 15mL | 29.99mL |
| 5mM | 0.6mL | 3mL | 6mL |
| 10mM | 0.3mL | 1.5mL | 3mL |
| 50mM | 0.06mL | 0.3mL | 0.6mL |
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