BiologicalActivity
PotentandselectiveCRF1receptorantagonist(Kivaluesare12and>10000nMforCRF1andCRF2receptorsrespectively).AttenuatesCRF-inducedactivationoftheHPAaxisinvivofollowingi.v.administration.Orallyactive.
CompoundLibraries
CP376395hydrochlorideisalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 362.94 |
| Formula | C21H30N2O.HCl |
| Storage | DesiccateatRT |
| Purity | ≥99%(HPLC) |
| CASNumber | 1013933-37-3 |
| PubChemID | 24806455 |
| InChIKey | UDIOZDHQQNYISB-UHFFFAOYSA-N |
| Smiles | CC1=CC(NC(CC)CC)=C(C)C(OC2=C(C)C=C(C)C=C2C)=N1.Cl |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| 1eq.HCl | 36.29 | 100 | |
| DMSO | 36.29 | 100 | |
| ethanol | 36.29 | 100 | |
| water | 18.15 | 50 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight362.94.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.76mL | 13.78mL | 27.55mL |
| 5mM | 0.55mL | 2.76mL | 5.51mL |
| 10mM | 0.28mL | 1.38mL | 2.76mL |
| 50mM | 0.06mL | 0.28mL | 0.55mL |
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