生命科学Tocris价格优惠中国Tocris Bioscience公司,Tocris/CU CPT 4a/4883/10/10 mg,受体,生物分子,生化试剂,,Tocris Bioscience蚂蚁淘商城

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Tocris/CU CPT 4a/4883/10/10 mg

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Tocris

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4883/10

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4000-520-616

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Description:SelectiveTLR3inhibitor

ChemicalName:N-[(3-Chloro-6-fluorobenzo[b]thien-2-yl)carbonyl]-D-phenylalanine

Purity:≥98%(HPLC)

BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

SelectiveTLR3inhibitor(IC₅₀=3.44μMinRAW264.7cells);suppressesdownstreamsignalingpathwaysmediatedbytheTLR3/dsRNAcomplex,inhibitingTNF-αandIL-1βproductioninwholecells.Reducesdeathofcryptcellsandimprovesgastrointestinalsyndromeinmice.

LicensingInformation

SoldunderlicensefromtheUniversityofColorado

CompoundLibraries

CUCPT4aisalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.

TechnicalData

M.Wt	377.82
Formula	C₁₈H₁₃ClFNO₃S
Storage	Storeat+4°C
Purity	≥98%(HPLC)
CASNumber	1279713-77-7
PubChemID	53242268
InChIKey	IAASQMCXDRISAV-CYBMUJFWSA-N
Smiles	O=C(N[C@H](CC3=CC=CC=C3)[C@@](O)=O)C2=C(Cl)C1=CC=C(F)C=C1S2

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

	Solvent	MaxConc.mg/mL	MaxConc.mM
Solubility
	1eq.NaOH	18.89	50
	DMSO	37.78	100

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight377.82.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	2.65mL	13.23mL	26.47mL
5mM	0.53mL	2.65mL	5.29mL
10mM	0.26mL	1.32mL	2.65mL
50mM	0.05mL	0.26mL	0.53mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet

SafetyDatasheet

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