BiologicalActivity
Potentβ-adrenoceptorandα1-adrenoceptorantagonist(Kivaluesare0.81,0.96and2.2nMforβ1-,β2-andα1-adrenoceptorsrespectively)thatdisplaysantihypertensiveandperipheralvasodilatoryactivity.Blockscardiacinward-rectifierK+(KIR)channels,voltage-dependentCa2+channelsandexhibitsantioxidantpropertiesathigherconcentrations.
CompoundLibraries
CarvedilolisalsoofferedaspartoftheTocriscreenPlusandTocriscreenLibraryofFDA-ApprovedCompounds.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 406.47 |
| Formula | C24H26N2O4 |
| Storage | Storeat+4°C |
| Purity | ≥99%(HPLC) |
| CASNumber | 72956-09-3 |
| PubChemID | 2585 |
| InChIKey | OGHNVEJMJSYVRP-UHFFFAOYSA-N |
| Smiles | COC1=C(OCCNCC(O)COC2=CC=CC3=C2C2=C(N3)C=CC=C2)C=CC=C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 40.64 | 100 | |
| ethanol | 20.32 | 50 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight406.47.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.46mL | 12.3mL | 24.6mL |
| 5mM | 0.49mL | 2.46mL | 4.92mL |
| 10mM | 0.25mL | 1.23mL | 2.46mL |
| 50mM | 0.05mL | 0.25mL | 0.49mL |
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