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Tocris/Cevimeline hydrochloride/3689/50/50 mg

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Tocris/Cevimeline hydrochloride/3689/50/50 mg

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Tocris

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3689/50

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4000-520-616

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Description:SelectiveM₁agoNIST

AlternativeNames:AF102B,SNI2011

ChemicalName:cis-2-Methylspiro[1,3-oxathiolane-5,3'-quinuclidine]hydrochloride

BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

SelectiveM₁receptoragonist.Inducesatropine-sensitivecontractionsofisolatedguineapigileaandtracheapreparations(EC₅₀valuesare3.5and3μMrespectively).ReversesAF64A-inducedcognitiveimpairmentsinvivo.

TechnicalData

M.Wt	235.77
Formula	C₁₀H₁₇NOS.HCl
Storage	Storeat-20°C
CASNumber	107220-28-0
PubChemID	76965955
InChIKey	SKFLGMLYGHWKJG-RXUMEZLZSA-N
Smiles	C[C@@H](SC3)O[C@@]13CN2CCC1CC2.C[C@H](SC6)O[C@]46CN5CCC4CC5.Cl.Cl

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

	Solvent	MaxConc.mg/mL	MaxConc.mM
Solubility
	DMSO	11.79	50
	water	17.68	75

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight235.77.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	4.24mL	21.21mL	42.41mL
5mM	0.85mL	4.24mL	8.48mL
10mM	0.42mL	2.12mL	4.24mL
50mM	0.08mL	0.42mL	0.85mL

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