BiologicalActivity
Calcium-sensingreceptor(CaSR)allostericagonist.ActivatesCaSRsignalingincellularproliferationandphosphatidylinositol(PI)hydrolysisassays.Reducesserumparathyroidhormonelevelsinrats.AlsopotentCYP2D2inhibitor(IC50=87nM)andL-typecalciumchannelblocker.Orallybioavailable.
TechnicalData
| M.Wt | 393.87 |
| Formula | C22H22F3N.HCl |
| Storage | Storeat-20°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 364782-34-3 |
| PubChemID | 156418 |
| InChIKey | QANQWUQOEJZMLL-PKLMIRHRSA-N |
| Smiles | C[C@H](C1=CC=CC2=C1C=CC=C2)NCCCC3=CC(C(F)(F)F)=CC=C3.Cl |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 39.39 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight393.87.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.54mL | 12.69mL | 25.39mL |
| 5mM | 0.51mL | 2.54mL | 5.08mL |
| 10mM | 0.25mL | 1.27mL | 2.54mL |
| 50mM | 0.05mL | 0.25mL | 0.51mL |
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