BiologicalActivity
Freefattyacidreceptor1(FFA1/GPR40)antagonist.InhibitsFFA-inducedincreasesinintracellularCa2+levelsandsuppressespalmiticacidpotentiatedglucose-stimulatedinsulinsecretioninMin6pancreaticβcellsinvitro.Decreasesseruminsulinlevels,improvesinsulinsensitivityandreducesthenumberofapoptoticpancreaticβcellsinobesediabetic(db/db)rats.
CompoundLibraries
DC260126isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 307.38 |
| Formula | C16H18FNO2S |
| Storage | Storeat-20°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 346692-04-4 |
| PubChemID | 2843133 |
| InChIKey | CNGHPXKWPGIDSK-UHFFFAOYSA-N |
| Smiles | CCCCC(C=C2)=CC=C2NS(C1=CC=C(F)C=C1)(=O)=O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 30.74 | 100 | |
| ethanol | 30.74 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight307.38.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 3.25mL | 16.27mL | 32.53mL |
| 5mM | 0.65mL | 3.25mL | 6.51mL |
| 10mM | 0.33mL | 1.63mL | 3.25mL |
| 50mM | 0.07mL | 0.33mL | 0.65mL |
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