BiologicalActivity
NovelallostericpotentiatorofthemetabotropicglutamatereceptormGlu5.DevoidofagoNISTactivityitself,butpotentiates(3-6-fold)theactionofagonistsatmGlu5withoutanyeffectatothermGlusubtypes(EC50forpotentiation=2-5.3μM).
TechnicalData
| M.Wt | 244.24 |
| Formula | C14H10F2N2 |
| Storage | Storeat+4°C |
| Purity | ≥99%(HPLC) |
| CASNumber | 15332-10-2 |
| PubChemID | 52942441 |
| InChIKey | DYNGCIHMNWOBSU-MSQVLRTGSA-K |
| Smiles | FC1=CC(=CC=C1)C=NN=CC1=CC=CC(F)=C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 12.21 | 50 | |
| ethanol | 2.44 | 10 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight244.24.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 4.09mL | 20.47mL | 40.94mL |
| 5mM | 0.82mL | 4.09mL | 8.19mL |
| 10mM | 0.41mL | 2.05mL | 4.09mL |
| 50mM | 0.08mL | 0.41mL | 0.82mL |
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