BiologicalActivity
Activeisomerofmedetomidine(Cat.No.5160),apotent,highlyselectiveα2-adrenoceptoragonist(Kivaluesare1.08and1750nMforα2-andα1-adrenoceptorsrespectively).Displaysgreaterselectivityoverα1-adrenoceptorsthanclonidineandUK14,304(1620-,220-and300-foldrespectively).Activeinvivo;displayshypotensive,bradycardic,sedative,anxiolytic,hypothermicandanalgesiceffects.
CompoundLibraries
DexmedetomidinehydrochlorideisalsoofferedaspartoftheTocriscreenPlusandTocriscreenLibraryofFDA-ApprovedCompounds.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 236.74 |
| Formula | C13H16N2.HCl |
| Storage | DesiccateatRT |
| Purity | ≥99%(HPLC) |
| CASNumber | 145108-58-3 |
| PubChemID | 6918081 |
| InChIKey | VPNGEIHDPSLNMU-MERQFXBCSA-N |
| Smiles | C[C@H](C2=CN=CN2)C1=C(C)C(C)=CC=C1.Cl |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 23.67 | 100 | |
| ethanol | 5.92 | 25 | |
| water | 23.67 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight236.74.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 4.22mL | 21.12mL | 42.24mL |
| 5mM | 0.84mL | 4.22mL | 8.45mL |
| 10mM | 0.42mL | 2.11mL | 4.22mL |
| 50mM | 0.08mL | 0.42mL | 0.84mL |
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