BiologicalActivity
Enantiomerthatisasubtype-selectiveM2muscarinicreceptorantagonist(pKivaluesare7.08,7.78,6.70and7.00forM1,M2,M3andM4receptorsrespectively).AlsoH1histaminereceptorantagonist(pKi=7.48).Allowsformationofextendedpluripotentstem(EPS)cellsincombinationwithCHIR99021(Cat.No.4423),minocyclinehydrochloride(Cat.No.3268)andhumanleukemiainhibitoryfactor.
TechnicalData
| M.Wt | 408.5 |
| Formula | C20H24N2.C4H4O4 |
| Storage | DesiccateatRT |
| Purity | ≥99%(HPLC) |
| CASNumber | 136152-65-3 |
| PubChemID | 56972160 |
| InChIKey | SWECWXGUJQLXJF-HFNHQGOYSA-N |
| Smiles | C[C@H](C3=NC=CC=C3)C2=C(CCN(C)C)CC1=CC=CC=C12.OC(=O)C=C/C(O)=O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 40.85 | 100 | |
| water | 29.24 | 100mMwithgentlewarming |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight408.5.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.45mL | 12.24mL | 24.48mL |
| 5mM | 0.49mL | 2.45mL | 4.9mL |
| 10mM | 0.24mL | 1.22mL | 2.45mL |
| 50mM | 0.05mL | 0.24mL | 0.49mL |
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