BiologicalActivity
VitaminDreceptor(VDR)agonist;analogofcalcitriol(Cat.No.2551).Exhibitsanti-tumorandanti-proliferativeactivitywithreducedhypercalcemiceffects.60timesmorepotentininhibitingMCF-7cellgrowthinvitro;alsoshowntoinduceautophagyinMCF-7cells.Reversestheeffectsofparathyroidhormone-relatedprotein(PTHrP).
TechnicalData
| M.Wt | 454.68 |
| Formula | C30H46O3 |
| Storage | Storeat-20°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 134404-52-7 |
| PubChemID | 5288149 |
| InChIKey | LVLLALCJVJNGQQ-SEODYNFXSA-N |
| Smiles | C[C@@](CCC2)3[C@](CC[C@@]([H])3[C@@H](/C=C/C=C/C(CC)(O)CC)C)([H])/C2=C/C=C(C[C@@H](O)C[C@@H]1O)C1=C |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solubility | SolubleinDMSOandinethanol |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight454.68.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.2mL | 11mL | 21.99mL |
| 5mM | 0.44mL | 2.2mL | 4.4mL |
| 10mM | 0.22mL | 1.1mL | 2.2mL |
| 50mM | 0.04mL | 0.22mL | 0.44mL |
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