BiologicalActivity
Selectivemineralocorticoid(aldosterone)receptorantagonist(IC50=360nM).Displays>27-foldselectivityoverandrogen,progesteroneandestrogenreceptors(IC50>10μM).Orallyactiveantihypertensiveinvivo.
TechnicalData
| M.Wt | 414.5 |
| Formula | C24H30O6 |
| Storage | StoreatRT |
| Purity | ≥99%(HPLC) |
| CASNumber | 107724-20-9 |
| PubChemID | 443872 |
| InChIKey | JUKPWJGBANNWMW-VWBFHTRKSA-N |
| Smiles | O=C1CC[C@@]2(C)C(C[C@@H]([C@](OC)=O)[C@]3([H])[C@@](O6)2[C@H]6C[C@@]4(C)[C@]([H])3CC[C@@]54OC(CC5)=O)=C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 4.14 | 10 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight414.5.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.41mL | 12.06mL | 24.13mL |
| 5mM | 0.48mL | 2.41mL | 4.83mL |
| 10mM | 0.24mL | 1.21mL | 2.41mL |
| 50mM | 0.05mL | 0.24mL | 0.48mL |
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