BiologicalActivity
Potentandselective5-HT2Aantagonist(IC50valuesare5.8and120and>100nMfor5-HT2A,5-HT2Band5-HT2C,respectively).Attenuatescocaine-inducedhyperactivity.Increasesdopamine(DA)releaseinratmedialprefrontalcortex(mPFC);potentiateshaloperidol-inducedDAreleaseinthemPFCandnucleusaccumbens.
TechnicalData
| M.Wt | 386.42 |
| Formula | C19H21FN2O2.0.5C4H4O4 |
| Storage | Storeat+4°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 130580-02-8 |
| PubChemID | 6438382 |
| InChIKey | UCLIFEBROADCQW-PWERMGERSA-N |
| Smiles | OC(C=C2)=CC=C2/C=C/C(C1=CC=CC=C1F)=N/OCCN(C)C.O=C(/C=C/C(O)=O)O.OC(C=C4)=CC=C4/C=C/C(C3=CC=CC=C3F)=N/OCCN(C)C |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 19.32 | 50 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight386.42.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.59mL | 12.94mL | 25.88mL |
| 5mM | 0.52mL | 2.59mL | 5.18mL |
| 10mM | 0.26mL | 1.29mL | 2.59mL |
| 50mM | 0.05mL | 0.26mL | 0.52mL |
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