BiologicalActivity
SelectiveprostanoidEP4receptorcompetitiveantagonistwithadditionalaffinityatTPreceptors(pKivaluesare7.0and6.8incompetitionrADIoligandbioassays).Affinityforallotherprostanoidreceptorsis<5.3.InhibitsU-46619inducedhumanplateletaggregation.
LicensingInformation
SoldforresearchpurposesunderagreementfromGlaxoSmithKline.
CompoundLibraries
GW627368isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 544.62 |
| Formula | C30H28N2O6S |
| Storage | Storeat-20°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 439288-66-1 |
| PubChemID | 5312130 |
| InChIKey | XREWXJVMYAXCJV-UHFFFAOYSA-N |
| Smiles | O=C(NS(C5=CC=CC=C5)(=O)=O)CC(C=C4)=CC=C4N3CC2=C(OCC)C1=CC=CC=C1C(OCC)=C2C3=O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 54.46 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight544.62.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 1.84mL | 9.18mL | 18.36mL |
| 5mM | 0.37mL | 1.84mL | 3.67mL |
| 10mM | 0.18mL | 0.92mL | 1.84mL |
| 50mM | 0.04mL | 0.18mL | 0.37mL |
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