BiologicalActivity
PotentandhighlyselectivePPARαagonist(EC50valuesare6,1100and6200nMforhumanPPARα,PPARγandPPARδreceptorsrespectively).Modulatesoleatemetabolismandmitochondrialenzymegeneexpressioninmaturemyotubulesinvitro.Haslipid-loweringeffectsfollowingoraladministrationinvivo.ReducesNOproductioninmacrophages;exhibitsanti-inflammatoryproperties.
LicensingInformation
SoldforresearchpurposesunderagreementfromGlaxoSmithKline
CompoundLibraries
GW7647isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 502.75 |
| Formula | C29H46N2O3S |
| Storage | StoreatRT |
| Purity | ≥99%(HPLC) |
| CASNumber | 265129-71-3 |
| PubChemID | 3392731 |
| InChIKey | PKNYXWMTHFMHKD-UHFFFAOYSA-N |
| Smiles | CC(C)(SC1=CC=C(CCN(CCCCC2CCCCC2)C(=O)NC2CCCCC2)C=C1)C(O)=O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 50.27 | 100 | |
| ethanol | 12.57 | 25 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight502.75.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 1.99mL | 9.95mL | 19.89mL |
| 5mM | 0.4mL | 1.99mL | 3.98mL |
| 10mM | 0.2mL | 0.99mL | 1.99mL |
| 50mM | 0.04mL | 0.2mL | 0.4mL |
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ProductDatasheets
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