BiologicalActivity
Selective,highaffinitytachykininNK1receptorantagonist(Ki=0.69nM)thatdisplays320-foldselectivityforhumanoverratNK1receptors.InhibitssubstanceP-inducedcontractionofisolatedguineapigtrachea(IC50=32nM)andinhibitssubstanceP-inducedairwayconstrictioninvivofollowingi.v.andoraladministration.
LicensingInformation
SoldwiththepermissionofAstellasPharmaInc.
CompoundLibraries
FK888isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 588.69 |
| Formula | C36H36N4O4 |
| Storage | Storeat-20°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 138449-07-7 |
| PubChemID | 107967 |
| InChIKey | BFNKQTIJVFGCKQ-PDJGWCFMSA-N |
| Smiles | O=C(N3[C@H]([C@](N[C@@H](CC5=CC(C=CC=C6)=C6C=C5)C(N(C)CC4=CC=CC=C4)=O)=O)C[C@@H](O)C3)C2=CN(C)C1=CC=CC=C12 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 58.87 | 100 | |
| ethanol | 58.87 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight588.69.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 1.7mL | 8.49mL | 16.99mL |
| 5mM | 0.34mL | 1.7mL | 3.4mL |
| 10mM | 0.17mL | 0.85mL | 1.7mL |
| 50mM | 0.03mL | 0.17mL | 0.34mL |
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