BiologicalActivity
S1Preceptoragonist;undergoesphosphorylationbysphingosinekinase2,whichthenbindsS1P1,3,4and5receptors(EC50valuesare0.3-0.6nMforS1P1,4and5and~3nMforS1P3).Immunosuppresant;sequesterslymphocytesinlymphnodes,reducingautoimmuneresponse.SuppressesthedevelopmentofEAE(aninvivomodelofMS).Orallybioavailableandblood-brainbarrierpermeable.
CompoundLibraries
FTY720isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 343.93 |
| Formula | C19H33NO2.HCl |
| Storage | Storeat-20°C |
| Purity | ≥99%(HPLC) |
| CASNumber | 162359-56-0 |
| PubChemID | 107969 |
| InChIKey | SWZTYAVBMYWFGS-UHFFFAOYSA-N |
| Smiles | CCCCCCCCC1=CC=C(C=C1)CCC(CO)(CO)N.Cl |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| water | 34.39 | 100 | |
| DMSO | 34.39 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight343.93.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.91mL | 14.54mL | 29.08mL |
| 5mM | 0.58mL | 2.91mL | 5.82mL |
| 10mM | 0.29mL | 1.45mL | 2.91mL |
| 50mM | 0.06mL | 0.29mL | 0.58mL |
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