BiologicalActivity
Potentandselectivenon-competitivemGlu5antagonistthatdisplaysinverseagonistproperties;blocksmGlu5constitutiveactivityinvitro(IC50=87nM).ActsatanallostericmodulatorysitesharedwithMPEPandbindsthemGlu5receptorwithKdvaluesof54and31nMforratandhumanreceptorsrespectively.Displaysanxiolyticactivityfollowingoraladministrationinvivo;alsoexhibitsanalgesicproperties.
CompoundLibraries
FenobamisalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 266.69 |
| Formula | C11H11N4O2Cl |
| Storage | StoreatRT |
| Purity | ≥99%(HPLC) |
| CASNumber | 57653-26-6 |
| PubChemID | 162834 |
| InChIKey | DWPQODZAOSWNHB-UHFFFAOYSA-N |
| Smiles | CN1CC(=O)N=C1NC(=O)NC1=CC(Cl)=CC=C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 26.67 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight266.69.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 3.75mL | 18.75mL | 37.5mL |
| 5mM | 0.75mL | 3.75mL | 7.5mL |
| 10mM | 0.37mL | 1.87mL | 3.75mL |
| 50mM | 0.07mL | 0.37mL | 0.75mL |
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