BiologicalActivity
Highaffinity,selectiveglucocorticoidreceptoragonist(Kd=0.5nM).Potentlystimulatesglucocorticoidreceptor-mediatedtransactivationofgeneexpressionandenhanceshumaneosinophilapoptosis(EC50=3.7nM)invitro.Inhibitsmastcellaccumulationinnasalmucosafollowingtopicaladministration.Lipophilicanti-inflammatoryagentwithloworalbioavailABIlity.AlsopotentiatesKV1channels(EC50=37nM).
LicensingInformation
SoldforresearchpurposesunderagreementfromGlaxoSmithKline
CompoundLibraries
FluticasonepropionateisalsoofferedaspartoftheTocriscreenPlusandTocriscreenLibraryofFDA-ApprovedCompounds.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 500.57 |
| Formula | C25H31F3O5S |
| Storage | StoreatRT |
| Purity | ≥98%(HPLC) |
| CASNumber | 80474-14-2 |
| PubChemID | 444036 |
| InChIKey | WMWTYOKRWGGJOA-CENSZEJFSA-N |
| Smiles | O=C1C=C[C@@]2(C)C([C@@H](F)C[C@]3([H])[C@@](F)2[C@@H](O)C[C@@]4(C)[C@]([H])3C[C@@H](C)[C@](C(SCF)=O)4OC(CC)=O)=C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 25.03 | 50 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight500.57.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2mL | 9.99mL | 19.98mL |
| 5mM | 0.4mL | 2mL | 4mL |
| 10mM | 0.2mL | 1mL | 2mL |
| 50mM | 0.04mL | 0.2mL | 0.4mL |
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