BiologicalActivity
Thyromimetic;highaffinityagonistatthyroidhormonereceptor(TR)βandTRαreceptors(KDvaluesare67and440pMrespectively).Displays5-and100-foldgreaterpotencythantheendogenousagonistT3invitroatTRα1andTRβ1receptorsrespectively.Promotesreversecholesteroltransportinchow-andfat-fedmice.Inducesproliferationofhepatocytesandpancreaticacinarcellsinratsindependentofpriortissueinjury.
CompoundLibraries
GC1isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 328.4 |
| Formula | C20H24O4 |
| Storage | Storeat-20°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 211110-63-3 |
| PubChemID | 9862248 |
| InChIKey | QNAZTOHXCZPOSA-UHFFFAOYSA-N |
| Smiles | CC1=CC(OCC(O)=O)=CC(C)=C1CC2=CC(C(C)C)=C(O)C=C2 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 32.84 | 100 | |
| ethanol | 32.84 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight328.4.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 3.05mL | 15.23mL | 30.45mL |
| 5mM | 0.61mL | 3.05mL | 6.09mL |
| 10mM | 0.3mL | 1.52mL | 3.05mL |
| 50mM | 0.06mL | 0.3mL | 0.61mL |
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