Tocris试剂采购 Tocris信号通路抑制剂,Tocris/GLPG 0974/5621/10/10 mg,受体,生物分子,生化试剂,,Tocris Bioscience蚂蚁淘商城

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Tocris/GLPG 0974/5621/10/10 mg

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Tocris

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5621/10

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Description:PotentFFA2antagoNIST

ChemicalName:4-[[[(2R)-1-(Benzo[b]thien-3-ylcarbonyl)-2-methyl-2-azetidinyl]carbonyl][(3-chlorophenyl)methyl]amino]butanoicacid

Purity:≥98%(HPLC)

BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

PotentFFA2antagonist(IC₅₀=9nM).ExhibitsselectivityforFFA2overFFA3.Inhibitsacetate-inducedhumanneutrophilmigrationinplasmaorbuffer.AlsoinhibitsFFA2-inducedexpressionofCD11bactivation-specificepitope(AE)inhumanwholeblood.Orallybioavailable.

TechnicalData

M.Wt	485
Formula	C₂₅H₂₅ClN₂O₄S
Storage	Storeat+4°C
Purity	≥98%(HPLC)
CASNumber	1391076-61-1
PubChemID	57520598
InChIKey	MPMKMQHJHDHPBE-RUZDIDTESA-N
Smiles	O=C(N1[C@](C(N(CC2=CC(Cl)=CC=C2)CCCC(O)=O)=O)(C)CC1)C3=CSC4=C3C=CC=C4

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

	Solvent	MaxConc.mg/mL	MaxConc.mM
Solubility
	1eq.NaOH	9.7	20mMwithgentlewarming
	DMSO	48.5	100
	ethanol	48.5	100

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight485.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	2.06mL	10.31mL	20.62mL
5mM	0.41mL	2.06mL	4.12mL
10mM	0.21mL	1.03mL	2.06mL
50mM	0.04mL	0.21mL	0.41mL

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