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Description:GPBAreceptor(TGR5)agoNIST
ChemicalName:4-[[3,5-Bis(trifluoromethyl)phenyl]methyl]-6-(2-fluorophenyl)-4,5-dihydro-pyrido[3,2-f]-1,4-oxazepin-3(2H)-one
Purity:≥98%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences
BiologicalActivity
GPBAreceptoragonist.UpregulatesGLP-1secretionfromintestinalcultures.IncreasesMQAE-fluorescencesuggestingadecreaseinintracellularchlorideconcentrationingallbladderepithelialcells.
CompoundLibraries
GPBAR-AisalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
M.Wt | 484.37 |
Formula | C23H15F7N2O2 |
Storage | Storeat-20°C |
Purity | ≥98%(HPLC) |
CASNumber | 877052-79-4 |
PubChemID | 11656002 |
InChIKey | ZIXNJVGTAXRKAP-UHFFFAOYSA-N |
Smiles | O=C(CO3)N(CC4=CC(C(F)(F)F)=CC(C(F)(F)F)=C4)CC1=C3N=CC=C1C2=C(F)C=CC=C2 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 48.44 | 100 | |
ethanol | 9.69 | 20 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight484.37.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 2.06mL | 10.32mL | 20.65mL |
5mM | 0.41mL | 2.06mL | 4.13mL |
10mM | 0.21mL | 1.03mL | 2.06mL |
50mM | 0.04mL | 0.21mL | 0.41mL |
MolarityCalculator
MolarityCalculator
Calculatethemass,volume,orconcentrationrequiredforasolution.
ReconstitutionCalculator
ReconstitutionCalculator
DilutionCalculator
DilutionCalculator
Calculatethedilutionrequiredtoprepareastocksolution.
ProductDatasheets
CertificateofAnalysis/ProductDatasheet
SafetyDatasheet
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