Tocris厂家直采，平行进口品牌试剂实验Tocris Bioscience代理,Tocris/GR 159897/1274/10/10 mg,受体,生物分子,生化试剂,,Tocris Bioscience蚂蚁淘商城

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Tocris/GR 159897/1274/10/10 mg

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Tocris

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1274/10

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Description:Non-peptide,potentNK₂antagoNIST

ChemicalName:5-Fluoro-3-[2-[4-methoxy-4-[[(R)-phenylsulphinyl]methyl]-1-piperidinyl]ethyl]-1H-indole

Purity:≥97%(HPLC)

BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

Apotent,selective,non-peptide,orallyactiveneurokininNK₂receptorantagonist.Competesforbindingof[³H]GR100679tohNK₂-transfectedCHOcellswithapK_iof9.5.InhibitsNK₂receptor-mediatedcontractionofguineapigtracheawithapA₂of8.7.Anxiolyticinvivo.

LicensingInformation

SoldwiththepermissionofGlaxoSmithKline

CompoundLibraries

GR159897isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.

TechnicalData

M.Wt	414.54
Formula	C₂₃H₂₇FN₂O₂S
Storage	Desiccateat-20°C
Purity	≥97%(HPLC)
CASNumber	158848-32-9
PubChemID	9953599
InChIKey	BANYJBHWTOJQDU-GDLZYMKVSA-N
Smiles	FC1=CC=C2C(C(CCN3CCC(C[S@@+]([O-])C4=CC=CC=C4)(OC)CC3)=CN2)=C1

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

	Solvent	MaxConc.mg/mL	MaxConc.mM
Solubility
	DMSO	20.73	50
	ethanol	4.15	10

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight414.54.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	2.41mL	12.06mL	24.12mL
5mM	0.48mL	2.41mL	4.82mL
10mM	0.24mL	1.21mL	2.41mL
50mM	0.05mL	0.24mL	0.48mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet

SafetyDatasheet

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