BiologicalActivity
PositiveallostericmodulatorofGABABreceptorfunction.PotentiatestheeffectsofGABAon[35S]GTPγSbindingatrecombinantandnativeGABABreceptors(EC50valuesare2.1and3.1μMrespectively).Decreasescocaineself-admiNISTration,blockstherewardingpropertiesofnicotineandproducesanxiolytic-likeactivitywithoutthesideeffectsassociatedwithbaclofenorbenzodiazepines.
TechnicalData
| M.Wt | 337.44 |
| Formula | C15H23N5O2S |
| Storage | StoreatRT |
| Purity | ≥98%(HPLC) |
| CASNumber | 39069-52-8 |
| PubChemID | 6604928 |
| InChIKey | GSGVDKOCBKBMGG-UHFFFAOYSA-N |
| Smiles | CSC1=NC(NC2CCCC2)=C(C(NC2CCCC2)=N1)[N+]([O-])=O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 3.37 | 10 | |
| ethanol | 1.69 | 5 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight337.44.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.96mL | 14.82mL | 29.63mL |
| 5mM | 0.59mL | 2.96mL | 5.93mL |
| 10mM | 0.3mL | 1.48mL | 2.96mL |
| 50mM | 0.06mL | 0.3mL | 0.59mL |
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