BiologicalActivity
Smoothened(Smo)receptoragonist(EC50=1.2μM).Doesnotrecognizetheclassiccyclopamine(Cat.No.1623)bindingsite.DoesnotpromoteSmotranslocationtotheprimarycilium;isstronglypotentiatedbyforskolinandcholeratoxin.PromotesdifferentiationofmultipotentmesenchymalProgenitorcellsintoosteoblasts.
TechnicalData
| M.Wt | 450.53 |
| Formula | C26H30N2O5 |
| Storage | Storeat+4°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 300833-95-8 |
| PubChemID | 54683103 |
| InChIKey | MDLUYYGRCGDKGL-UHFFFAOYSA-N |
| Smiles | OC(C1=CC=CC=C1N2CCCCCC)=C(C(NC3=CC=C(C(OCCC)=O)C=C3)=O)C2=O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 2.25 | 5mMwithgentlewarming |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight450.53.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.22mL | 11.1mL | 22.2mL |
| 5mM | 0.44mL | 2.22mL | 4.44mL |
| 10mM | 0.22mL | 1.11mL | 2.22mL |
| 50mM | 0.04mL | 0.22mL | 0.44mL |
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