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Description:SelectivePPARδantagoNIST
ChemicalName:3-[[[2-Methoxy-4-(phenylamino)phenyl]amino]sulfonyl]-2-thiophenecarboxylicacidmethylester
Purity:≥99%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences
BiologicalActivity
SelectivePPARδantagonist(IC50valuesare0.155,>10and≥10μMatPPARδ,PPARαandPPARγrespectively).Exhibitsinverseagonisteffectswhenadministeredbyitself.
CompoundLibraries
GSK0660isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 418.49 |
| Formula | C19H18N2O5S2 |
| Storage | Storeat+4°C |
| Purity | ≥99%(HPLC) |
| CASNumber | 1014691-61-2 |
| PubChemID | 46233311 |
| InChIKey | NDFKBGWLUHKMFY-UHFFFAOYSA-N |
| Smiles | O=S(NC1=C(OC)C=C(NC3=CC=CC=C3)C=C1)(C2=C(C(OC)=O)SC=C2)=O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 41.85 | 100 | |
| ethanol | 4.18 | 10 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight418.49.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.39mL | 11.95mL | 23.9mL |
| 5mM | 0.48mL | 2.39mL | 4.78mL |
| 10mM | 0.24mL | 1.19mL | 2.39mL |
| 50mM | 0.05mL | 0.24mL | 0.48mL |
MolarityCalculator
MolarityCalculator
Calculatethemass,volume,orconcentrationrequiredforasolution.
ReconstitutionCalculator
ReconstitutionCalculator
DilutionCalculator
DilutionCalculator
Calculatethedilutionrequiredtoprepareastocksolution.
ProductDatasheets
CertificateofAnalysis/ProductDatasheet
SafetyDatasheet

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