Tocris试剂采购 Tocris GPCR ligands,Tocris/GSK 137647/5257/10/10 mg,受体,生物分子,生化试剂,,Tocris Bioscience蚂蚁淘商城

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Tocris/GSK 137647/5257/10/10 mg

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Tocris

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5257/10

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4000-520-616

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Description:PotentandselectiveFFA4(GPR120)agoNIST

ChemicalName:4-Methoxy-N-(2,4,6-trimethylphenyl)benzenesulfonamide

Purity:≥99%(HPLC)

BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

PotentandselectiveFFA4(GPR120)agonist(pEC₅₀valuesare6.3,6.2and6.1atthehuman,mouseandratreceptor,respectively).Exhibits≥100-foldselectivityagainstapanelof61targetsincludingFFA1,FFA2andFFA3.Enhancesglucose-stimulatedinsulinsecretioninMIN6cells.InducesintracellularcalciumaccumulationinU2OScells;thisactivityisinhibitedbyAH7614(Cat.No.5256).

LicensingInformation

SoldforresearchpurposesunderagreementfromGlaxoSmithKline

CompoundLibraries

GSK137647isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.

TechnicalData

M.Wt	305.39
Formula	C₁₆H₁₉NO₃S
Storage	StoreatRT
Purity	≥99%(HPLC)
CASNumber	349085-82-1
PubChemID	743974
InChIKey	FQUAFMNPXPXOJE-UHFFFAOYSA-N
Smiles	CC1=CC(C)=CC(C)=C1NS(C2=CC=C(OC)C=C2)(=O)=O

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

	Solvent	MaxConc.mg/mL	MaxConc.mM
Solubility
	DMSO	30.54	100
	ethanol	15.27	50

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight305.39.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	3.27mL	16.37mL	32.75mL
5mM	0.65mL	3.27mL	6.55mL
10mM	0.33mL	1.64mL	3.27mL
50mM	0.07mL	0.33mL	0.65mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet

SafetyDatasheet

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