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Description:SelectiveRev-ErbαagoNIST
AlternativeNames:SR6452
ChemicalName:1,1-Dimethylethyl-N-[(4-chlorophenyl)methyl]-N-[(5-nitro-2-thienyl)methyl])glycinate
Purity:≥98%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences
BiologicalActivity
SelectiveRev-Erbαagonist(EC50=250nM).Enhancesrecruitmentofnuclearreceptorco-repressor(NCoR)peptidetoRev-Erbα;causesacutesuppressionofBMAl1genetranscription.InducesphaseshiftsinthecircADIanclock.
TechnicalData
M.Wt | 396.89 |
Formula | C18H21ClN2O4S |
Storage | Storeat+4°C |
Purity | ≥98%(HPLC) |
CASNumber | 1216744-19-2 |
PubChemID | 50905018 |
InChIKey | WYSLOKHVFKLWOU-UHFFFAOYSA-N |
Smiles | CC(C)(C)OC(CN(CC2=CC=C(Cl)C=C2)CC1=CC=C([N+]([O-])=O)S1)=O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 9.92 | 25 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight396.89.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 2.52mL | 12.6mL | 25.2mL |
5mM | 0.5mL | 2.52mL | 5.04mL |
10mM | 0.25mL | 1.26mL | 2.52mL |
50mM | 0.05mL | 0.25mL | 0.5mL |
MolarityCalculator
MolarityCalculator
Calculatethemass,volume,orconcentrationrequiredforasolution.
ReconstitutionCalculator
ReconstitutionCalculator
DilutionCalculator
DilutionCalculator
Calculatethedilutionrequiredtoprepareastocksolution.
ProductDatasheets
CertificateofAnalysis/ProductDatasheet
SafetyDatasheet


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