BiologicalActivity
Potent,selectiveandorallyactivemelanin-concentratinghormonereceptor1(MCH1)antagonist(IC50valuesare13.5and>10000nMforMCH1andMCH2receptorsrespectively).Exhibitsanxiolyticandantidepressantactivityinrodents.Alsodisplaysaffinityfor5-HT2Band5-HT1Areceptors(IC50valuesare9.66and16.9nMrespectively).
TechnicalData
| M.Wt | 461.94 |
| Formula | C23H25F2N5O.HCl |
| Storage | Storeat+4°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 510733-97-8 |
| PubChemID | 9934032 |
| InChIKey | HUUPKFUYSQNNLO-UHFFFAOYSA-N |
| Smiles | O=C(C4=CC(F)=C(F)C=C4)N[C@@H](CC3)CC[C@@H]3NC2=NC1=CC=CC=C1C(N(C)C)=N2.Cl |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 4.62 | 10 | |
| ethanol | 11.55 | 25 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight461.94.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.16mL | 10.82mL | 21.65mL |
| 5mM | 0.43mL | 2.16mL | 4.33mL |
| 10mM | 0.22mL | 1.08mL | 2.16mL |
| 50mM | 0.04mL | 0.22mL | 0.43mL |
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