BiologicalActivity
Thestandardselective5-HT1Aagonist.Alsohasmoderateaffinityfor5-HT7receptors(pKiis6.6atthehuman5-HT7receptorexpressedinHEK293cells).Reduceshippocampal5-HTlevelsfollowingsystemicadministrationinratsinvivo.(R)-(+)-8-Hydroxy-DPAThydrobromide(Cat.No.1080)and7-Hydroxy-DPAThydrobromide(Cat.No.0706)alsoavailable.
TechnicalData
| M.Wt | 328.29 |
| Formula | C16H25NO.HBr |
| Storage | Desiccateat+4°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 76135-31-4 |
| PubChemID | 6917794 |
| InChIKey | BATPBOZTBNNDLN-UHFFFAOYSA-N |
| Smiles | Br.CCCN(CCC)C1CCC2=CC=CC(O)=C2C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| ethanol | 1.64 | 5 | |
| water | 6.57 | 20mMwithgentlewarming | |
| phosphatebufferedsaline | 4.92 | 15mMwithgentlewarming |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight328.29.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 3.05mL | 15.23mL | 30.46mL |
| 5mM | 0.61mL | 3.05mL | 6.09mL |
| 10mM | 0.3mL | 1.52mL | 3.05mL |
| 50mM | 0.06mL | 0.3mL | 0.61mL |
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