BiologicalActivity
Highlypotentselective5-HT1Areceptorfullagonist(pKivaluesare9.0,6.6,7.5,6.6and<6.0for5-HT1A,5-HT1B,5-HT1C,5-HT2and5-HT3receptorsrespectively).PossIBLybindsbetweentheagonistbindingsiteandtheGproteininteractionswitchsite,affectingtheactivationmechanism,andmaydisplaypositivecooperativity.Anxiolyticfollowingcentraladministrationinvivo.
CompoundLibraries
S14506hydrochlorideisalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 443.94 |
| Formula | C24H26FN3O2.HCl |
| Storage | DesiccateatRT |
| Purity | ≥99%(HPLC) |
| CASNumber | 286369-38-8 |
| PubChemID | 131905 |
| InChIKey | HWLZKPKZVOLFGK-UHFFFAOYSA-N |
| Smiles | Cl.COC1=CC2=C(C=CC=C2C=C1)N1CCN(CCNC(=O)C2=CC=C(F)C=C2)CC1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 40.75 | 100 | |
| ethanol | 4.07 | 10 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight443.94.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.25mL | 11.26mL | 22.53mL |
| 5mM | 0.45mL | 2.25mL | 4.51mL |
| 10mM | 0.23mL | 1.13mL | 2.25mL |
| 50mM | 0.05mL | 0.23mL | 0.45mL |
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